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Hypnotic doses of barbiturates usually do not surface to impair uterine exercise appreciably in the course of labor. Entire anesthetic doses of barbiturates reduce the pressure and frequency of uterine contractions. Administration of sedative-hypnotic barbiturates on the mother in the course of labor may possibly end in respiratory melancholy in th

phenobarbital increases toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. CYP3A4 inducers may perhaps enhance the metabolism of ifosfamide to its active alkylating metabolites.Keep an eye on Intently (1)somatropin will lower the extent or outcome of phenobarbital by influencing hepatic/intestina